Monograph

A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus

Molecular and cellular alterations underlying memory impairments in animal models of neurodegeneration
  • Daniele Lana,

Neurodegenerative processes alter neuronal and glial physiology and cause cognitive and mnemonic impairments. Aim of this PhD thesis is to investigate the involvement of the cholinergic system and the role of mTOR pathway in the mechanisms of memory encoding in the hippocampus and to study the pathophysiological processes at the base of the cognitive impairments in different experimental models of neurodegeneration: in particular normal brain aging, neuroinfiammation and chronic cerebral hypoperfusion. These mechanisms are studied focusing on the morpho-functional alterations in the neuron-astrocytemicroglia triad.

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Daniele Lana

University of Florence, Italy - ORCID: 0000-0002-5193-0019

Daniele Lana was born in Grosseto in 1980. He graduated in Biology in the University of Florence and received his PhD in “Pharmacology, Toxicology and Innovative Treatments” in 2014. His research work is focused on the mechanisms of memory formation and the neurodegenerative processes in the brain.
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PDF
  • Publication Year: 2015
  • Pages: 136
  • eISBN: 978-88-6655-941-2
  • Content License: CC BY 4.0
  • © 2015 Author(s)

XML
  • Publication Year: 2015
  • eISBN: 978-88-9273-311-4
  • Content License: CC BY 4.0
  • © 2015 Author(s)

PRINT
  • Publication Year: 2015
  • Pages: 136
  • eISBN: 978-88-6655-940-5
  • Content License: CC BY 4.0
  • © 2015 Author(s)

Bibliographic Information

Book Title

A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus

Book Subtitle

Molecular and cellular alterations underlying memory impairments in animal models of neurodegeneration

Authors

Daniele Lana

Peer Reviewed

Number of Pages

136

Publication Year

2015

Copyright Information

© 2015 Author(s)

Content License

CC BY 4.0

Metadata License

CC0 1.0

Publisher Name

Firenze University Press

DOI

10.36253/978-88-6655-941-2

ISBN Print

978-88-6655-940-5

eISBN (pdf)

978-88-6655-941-2

eISBN (xml)

978-88-9273-311-4

Series Title

Premio Tesi di Dottorato

Series ISSN

2612-8039

Series E-ISSN

2612-8020

388

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