Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems
- Elisabetta Coppi,
Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the activation of specific membrane receptors (P1 and P2) and their role as neurotransmitters began to be investigated. The present work was aimed to clarify the effects of purinergic neurotransmission in different cell systems by using electrophysiological techniques. Relevant results of this research include the observation that P1 and P2 receptors play a deleterious role during "in vitro" ischemia in the rat brain, and the first demonstration of P2 receptor expression and function in a line of adult human mesenchymal stem cells.
- Keywords:
- Chimica,
- Chimica inorganica,
- Fisiologia,
- Metabolismo,
- Acidi nucleici,
- Open Access,
- DOI: 10.36253/978-88-8453-905-2
- Series: Premio Tesi di Dottorato
- Scientific Board
- Language: English
- Subjects: Medicine
University of Florence, Italy - ORCID: 0000-0003-4434-5919
- Publication Year: 2008
- Pages: 192
- eISBN: 978-88-8453-905-2
- Content License: CC BY-ND 3.0 IT
- © 2008 Author(s)
- Publication Year: 2008
- eISBN: 978-88-9273-789-1
- Content License: CC BY-ND 3.0 IT
- © 2008 Author(s)
- Publication Year: 2008
- Pages: 192
- ISBN: 978-88-8453-904-5
- Content License: CC BY-ND 3.0 IT
- © 2008 Author(s)
Bibliographic Information
Book Title
Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems
Authors
Elisabetta Coppi
Peer Reviewed
Number of Pages
192
Publication Year
2008
Copyright Information
© 2008 Author(s)
Content License
Metadata License
Publisher Name
Firenze University Press
DOI
10.36253/978-88-8453-905-2
ISBN Print
978-88-8453-904-5
eISBN (pdf)
978-88-8453-905-2
eISBN (xml)
978-88-9273-789-1
Series Title
Premio Tesi di Dottorato
Series ISSN
2612-8039
Series E-ISSN
2612-8020
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