Monograph

Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems

  • Elisabetta Coppi,

Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the activation of specific membrane receptors (P1 and P2) and their role as neurotransmitters began to be investigated. The present work was aimed to clarify the effects of purinergic neurotransmission in different cell systems by using electrophysiological techniques. Relevant results of this research include the observation that P1 and P2 receptors play a deleterious role during "in vitro" ischemia in the rat brain, and the first demonstration of P2 receptor expression and function in a line of adult human mesenchymal stem cells.

  • Keywords:
  • Chimica,
  • Chimica inorganica,
  • Fisiologia,
  • Metabolismo,
  • Acidi nucleici,
  • Open Access,
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Elisabetta Coppi

University of Florence, Italy - ORCID: 0000-0003-4434-5919

Elisabetta Coppi in 2003 graduated in Biological Science with an experimental thesis. In April 2007 she get the PhD graduation in Pharmacology and Toxicology in the University of Florence and at present she works as a post-doctoral researcher on a project entitled "Study of the neurotransmission in monoaminergic nuclei and hippocampus from rodens in physiological conditions and during the treatment with antidepressant, ansiolytic and psychotropic drugs and/or amphetamine derivatives".
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Sommario

PDF
  • Publication Year: 2008
  • Pages: 192
  • eISBN: 978-88-8453-905-2
  • Content License: CC BY-ND 3.0 IT
  • © 2008 Author(s)

XML
  • Publication Year: 2008
  • eISBN: 978-88-9273-789-1
  • Content License: CC BY-ND 3.0 IT
  • © 2008 Author(s)

PRINT
  • Publication Year: 2008
  • Pages: 192
  • eISBN: 978-88-8453-904-5
  • Content License: CC BY-ND 3.0 IT
  • © 2008 Author(s)

Bibliographic Information

Book Title

Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems

Authors

Elisabetta Coppi

Peer Reviewed

Number of Pages

192

Publication Year

2008

Copyright Information

© 2008 Author(s)

Content License

CC BY-ND 3.0 IT

Metadata License

CC0 1.0

Publisher Name

Firenze University Press

DOI

10.36253/978-88-8453-905-2

ISBN Print

978-88-8453-904-5

eISBN (pdf)

978-88-8453-905-2

eISBN (xml)

978-88-9273-789-1

Series Title

Premio Tesi di Dottorato

Series Issn ISSN

2612-8039

Series E-Issn

2612-8020

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