Monograph

Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms

  • Serena Martinelli,

A gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). Enhanced activation of other downstream pathways including the PI3K/mTOR pathway has been documented as well. In this study we evaluated the effects of JAK1/2 inhibitors, alone and in combination with mTOR, with a dual mTOR/PI3K inhibitor and with a pan PI3K inhibitor in in-vitro and in-vivo MPN models. Our findings of strong synergy between the JAK2 inhibitors and mTOR/PI3K inhibitor suggested that we might be able to administer these drugs at lower concentrations than when the drugs are used individually. This provides a framework for combination trials using compounds in patients with myeloproliferative neoplasms

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Serena Martinelli

University of Florence, Italy

Serena Martinelli obtained the PhD title in Biomedical Science at Florence University in 2016. She is co-author in several articles and she is listed as the leading author in one of them. Her technical skills and competences are cellular biology, molecular biology and mouse models.
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  • Publication Year: 2017
  • Pages: 80
  • eISBN: 978-88-6453-565-4
  • Content License: CC BY 4.0
  • © 2017 Author(s)

XML
  • Publication Year: 2017
  • eISBN: 978-88-9273-168-4
  • Content License: CC BY 4.0
  • © 2017 Author(s)

PRINT
  • Publication Year: 2017
  • Pages: 80
  • eISBN: 978-88-6453-564-7
  • Content License: CC BY 4.0
  • © 2017 Author(s)

Bibliographic Information

Book Title

Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms

Authors

Serena Martinelli

Peer Reviewed

Number of Pages

80

Publication Year

2017

Copyright Information

© 2017 Author(s)

Content License

CC BY 4.0

Metadata License

CC0 1.0

Publisher Name

Firenze University Press

DOI

10.36253/978-88-6453-565-4

ISBN Print

978-88-6453-564-7

eISBN (pdf)

978-88-6453-565-4

eISBN (xml)

978-88-9273-168-4

Series Title

Premio Tesi di Dottorato

Series Issn ISSN

2612-8039

Series E-Issn

2612-8020

200

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