Monograph

Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms

  • Serena Martinelli,

A gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). Enhanced activation of other downstream pathways including the PI3K/mTOR pathway has been documented as well. In this study we evaluated the effects of JAK1/2 inhibitors, alone and in combination with mTOR, with a dual mTOR/PI3K inhibitor and with a pan PI3K inhibitor in in-vitro and in-vivo MPN models. Our findings of strong synergy between the JAK2 inhibitors and mTOR/PI3K inhibitor suggested that we might be able to administer these drugs at lower concentrations than when the drugs are used individually. This provides a framework for combination trials using compounds in patients with myeloproliferative neoplasms

+ Show More
Purchase

Serena Martinelli

University of Florence, Italy

Serena Martinelli obtained the PhD title in Biomedical Science at Florence University in 2016. She is co-author in several articles and she is listed as the leading author in one of them. Her technical skills and competences are cellular biology, molecular biology and mouse models.
Table of Contents

Indice

PDF
  • Publication Year: 2017
  • Pages: 80
  • eISBN: 978-88-6453-565-4
  • Content License: CC BY 4.0
  • © 2017 Author(s)

XML
  • Publication Year: 2017
  • eISBN: 978-88-9273-168-4
  • Content License: CC BY 4.0
  • © 2017 Author(s)

PRINT
  • Publication Year: 2017
  • Pages: 80
  • eISBN: 978-88-6453-564-7
  • Content License: CC BY 4.0
  • © 2017 Author(s)

Bibliographic Information

Book Title

Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms

Authors

Serena Martinelli

Peer Reviewed

Number of Pages

80

Publication Year

2017

Copyright Information

© 2017 Author(s)

Content License

CC BY 4.0

Metadata License

CC0 1.0

Publisher Name

Firenze University Press

DOI

10.36253/978-88-6453-565-4

ISBN Print

978-88-6453-564-7

eISBN (pdf)

978-88-6453-565-4

eISBN (xml)

978-88-9273-168-4

Series Title

Premio Tesi di Dottorato

Series Issn ISSN

2612-8039

Series E-Issn

2612-8020

214

Fulltext
downloads

608

Views

Search in This Book
Export Citation
Suggested Books

1,187

Open Access Books

in the Catalogue

886

Book Chapters

1,824,767

Fulltext
downloads

2,627

Authors

from 520 Research Institutions

of 51 Nations

50

scientific boards

from 276 Research Institutions

of 39 Nations

786

Referees

from 187 Research Institutions

of 32 Nations