Monograph

Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine

  • Caterina Bernacchioni,

This book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved.

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Caterina Bernacchioni

University of Florence, Italy - ORCID: 0000-0002-1023-0067

Caterina Bernacchioni (1981) was awarded a PhD in biochemistry and applied biology in 2011. Her scientific interests centre around studying the biological role of bioactive sphingolipids in the skeletal muscle and in stem cells. She is co-author of eleven publications in important international science journals and her research has been the subject of many papers at national and international conferences. At present she works at the University of Florence Department of Experimental and Clinical Biomedical Sciences.
Table of Contents
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  • Publication Year: 2012
  • Pages: 152
  • eISBN: 978-88-6655-219-2
  • Content License: CC BY-ND 3.0 IT
  • © 2012 Author(s)

XML
  • Publication Year: 2012
  • eISBN: 978-88-9273-564-4
  • Content License: CC BY-ND 3.0 IT
  • © 2012 Author(s)

PRINT
  • Publication Year: 2012
  • Pages: 116
  • eISBN: 978-88-6655-218-5
  • Content License: CC BY-ND 3.0 IT
  • © 2012 Author(s)

Bibliographic Information

Book Title

Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine

Authors

Caterina Bernacchioni

Peer Reviewed

Number of Pages

116

Publication Year

2012

Copyright Information

© 2012 Author(s)

Content License

CC BY-ND 3.0 IT

Metadata License

CC0 1.0

Publisher Name

Firenze University Press

DOI

10.36253/978-88-6655-219-2

ISBN Print

978-88-6655-218-5

eISBN (pdf)

978-88-6655-219-2

eISBN (xml)

978-88-9273-564-4

Series Title

Premio Tesi di Dottorato

Series Issn ISSN

2612-8039

Series E-Issn

2612-8020

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